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The Philadelphia 76ers are just 2.5-point underdogs against the Boston Celtics in the season opener for both teams at TD Garden on Wednesday, October 22, 2025. The game tips at 7:30 p.m. ET on NBCS-BOS and NBCS-PH.
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Celtics vs. 76ers Predictions for Wednesday
Our computer projections model for this matchup expects a final result of Celtics 122, 76ers 101.
- Moneyline Pick: Celtics (-143)
- Total Pick: Under 227.5 (computer predicts 223.4 points)
- Pick ATS: Celtics (-2.5)
Recent Celtics vs. 76ers Matchups
| Date | Favorite | Spread | Total | Favorite Moneyline | Underdog Moneyline | Result |
|---|---|---|---|---|---|---|
| 3/6/2025 | Celtics | -14 | 217.5 | -962 | +627 | 123-105 BOS |
| 2/20/2025 | Celtics | -7 | 225.5 | -296 | +239 | 124-104 BOS |
| 2/2/2025 | Celtics | -12.5 | 224.5 | -680 | +490 | 118-110 BOS |
| 12/25/2024 | Celtics | -9.5 | 221 | -427 | +330 | 118-114 PHI |
Celtics 2024-25 Betting Trends
- Boston's record against the spread last season was 39-43-0.
- Against the spread, as 2.5-point favorites or greater, the Celtics went 38-39 last year.
- Out of 82 Boston games last year, 37 went over the total.
- The Celtics went 60-18 in games they were favored on the moneyline last season (winning 76.9% of those games).
- Boston had a record of 58-17 when playing as a moneyline favorite with odds of -143 or shorter last year (77.3%).
76ers 2024-25 Betting Trends
- Philadelphia covered 29 times in 82 matchups with a spread last season.
- The 76ers went 21-27 as underdogs of 2.5 points or greater last season.
- A total of 48 of Philadelphia's games last season went over the point total.
- Last season, the 76ers won 10 out of the 53 games, or 18.9%, in which they were the underdog.
- Last season, Philadelphia won nine of its 47 games, or 19.1%, when it was the underdog by at least +120 on the moneyline.
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Celtics vs. 76ers Injury Report
Celtics
Celtics:
Jayson Tatum: Out (Achilles)
76ers
76ers:
Paul George: Day-To-Day (Knee),
Jared McCain: Out (Thumb)
Celtics vs. 76ers Game Time and TV Channel
- Game day: Wednesday, October 22, 2025
- Game time: 7:30 p.m. ET
- TV channel: NBCS-BOS and NBCS-PH
- Location: Boston, Massachusetts
- Arena: TD Garden
- Live stream: Watch this game on Fubo (Regional restrictions may apply)
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